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Name:   MartiniMan - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 8:57:11 AM

Am curious whether others will be willing to take the first vaccine that is widely available.  As of right now it looks like the Pfizer version may be the first available under the WarpSpeed program with 100M doses available in October.  According to research this vaccine approach has never been used in humans and comes with some potentially serious side effects (like all pharmacuticals it seems).

So the question is will you be first in line to get the vaccine or will you wait and see?





Name:   PTClakefan - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 9:10:30 AM

I'm retired so social distancing is working fine for me so far.  Don't think I want to be on the "bleeding-edge" of this one.





Name:   CRD - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 10:14:35 AM

For those in healthcare, it may be mandated in order to admit and maintain hospital privileges.  I see quite a war on the horizon.  





Name:   Shortbus - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 10:30:33 AM

So what is the percent chance of vaccine problems compared to the chance of the virus itself????

See meme.





Name:   wix - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 10:42:03 AM

I really doubt the vaccine will be approved without human trials....maybe reduced human studies, but not NONE.  As you say all drugs have the potential to cause reactions in some people....so be it.  Bring it on....I’m tired of Covid hysteria.





Name:   Talullahhound - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 10:51:05 AM

I've been thinking about this.   Since I'm retired, social distancing hasn't been too big a deal for me.  But at 65, I'm in the risk group.  I would like to go get my hair cut and resume some of my normal activities.  I won't rush to be first in line, but I will get it.  





Name:   MartiniMan - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 1:13:06 PM

I think that's quite correct.  So you go from being a lab rat with the virus to keep your job to being a forced rat lab for a vaccine to keep your job.  I really don't envy people in the healthcare industry.





Name:   GoneFishin - Email Member
Subject:   FAKE NEWS AND FAKE POLL
Date:   8/18/2020 1:28:20 PM (updated 8/18/2020 1:30:22 PM)

Martini, you are showing your ignorance unless you are trying to win votes for Trump with a vaccine before the election. You probably tried the bleach treatment before it was tested. Here is the true story...

August 17, 2020 04:41PM

 

Yale School of Medicine and Yale New Haven Hospital on Monday announced the start of Phase 3 of the Pfizer COVID-19 vaccine trial involving 30,000 volunteers at the hospital. 

This study is one of several vaccine trials undertaken in the race to stop the coronavirus. Pfizer, of Groton, was recently awarded $1.9 billion in federal funding to test and manufacture six million doses of vaccine, one million by year’s end. 

 Sanofi Pasteur, with a research and development facility in Meriden, was recently awarded $2.1 billion to test and manufacturer its vaccine candidate.   

“The Yale study is a collaboration between BioNTech SE and Pfizer using modified RNA,” a press release said. “Rather than using the part or whole of the actual virus in an inactive form to create immunity, this vaccine candidate uses a genetic code (modified RNA) to make the body generate proteins that resemble the SARS CoV-2 virus spike protein, thereby causing development of antibodies against it. Antibodies against the spike protein may block the infection from taking hold if the body comes in contact with the virus.”  

Phases 1 and 2 of the trial were recently peer reviewed in the scientific journal “Nature.” The review found the vaccine was safe and effective in generating an appropriate immune response. This third phase hopes to show that it can prevent infection.

“I am very excited that Yale New Haven Hospital and the Yale Center for Clinical Investigation  are undertaking this novel vaccine trial,” principal investigator Dr. Onyema E. Ogbuagu, said in the press release.

Ogbuagu is Yale New Haven Hospital’s infectious disease physician and associate professor of medicine at Yale School of Medicine.

 




Name:   MartiniMan - Email Member
Subject:   More Goofy stupidity on parade
Date:   8/18/2020 1:36:53 PM (updated 8/18/2020 2:21:20 PM)

Directly from Pfizer's website with my emphasis added.  Honestly, do you like being wrong all the time?  So my question remains....will you be in line to take it or wait and see?

PFIZER AND BIONTECH ANNOUNCE AN AGREEMENT WITH U.S. GOVERNMENT FOR UP TO 600 MILLION DOSES OF MRNA-BASED VACCINE CANDIDATE AGAINST SARS-COV-2

Wednesday, July 22, 2020 - 07:10am
  • U.S. government placed an initial order of 100 million doses for $1.95 billion and can acquire up to 500 million additional doses
  • Americans to receive the vaccine for free consistent with U.S. government’s commitment for free access for COVID-19 vaccines
  • Pfizer and BioNTech remain on track to begin an anticipated Phase 2b/3 safety and efficacy trial later this month, seek regulatory review as early as October 2020, and manufacture globally up to 100 million doses by the end of 2020 and potentially more than 1.3 billion doses by the end of 2021

NEW YORK & MAINZ, Germany--(BUSINESS WIRE)-- Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced the execution of an agreement with the U.S. Department of Health and Human Services and the Department of Defense to meet the U.S. government’s Operation Warp Speed program goal to begin delivering 300 million doses of a vaccine for COVID-19 in 2021. Under the agreement, the U.S. government will receive 100 million doses of BNT162, the COVID-19 vaccine candidate jointly developed by Pfizer and BioNTech, after Pfizer successfully manufactures and obtains approval or emergency use authorization from U.S. Food and Drug Administration (FDA).

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200722005438/en/

The U.S. government will pay the companies $1.95 billion upon the receipt of the first 100 million doses, following FDA authorization or approval. The U.S. government also can acquire up to an additional 500 million doses.

Americans will receive the vaccine for free consistent with U.S. government’s commitment for free access for COVID-19 vaccines.

“We’ve been committed to making the impossible possible by working tirelessly to develop and produce in record time a safe and effective vaccine to help bring an end to this global health crisis,” said Dr. Albert Bourla, Pfizer Chairman and CEO. “We made the early decision to begin clinical work and large-scale manufacturing at our own risk to ensure that product would be available immediately if our clinical trials prove successful and an Emergency Use Authorization is granted. We are honored to be a part of this effort to provide Americans access to protection from this deadly virus.”

“Expanding Operation Warp Speed’s diverse portfolio by adding a vaccine from Pfizer and BioNTech increases the odds that we will have a safe, effective vaccine as soon as the end of this year,” said HHS Secretary Alex Azar. “Depending on success in clinical trials, today’s agreement will enable the delivery of approximately 100 million doses of this vaccine to the American people.”

The BNT162 program is based on BioNTech’s proprietary mRNA technology and supported by Pfizer’s global vaccine development and manufacturing capabilities. The BNT162 vaccine candidates are undergoing clinical studies and are not currently approved for distribution anywhere in the world. BioNTech is the market authorization holder worldwide and will hold all trademarks for the potential product. Both collaborators are committed to developing these novel vaccines with pre-clinical and clinical data at the forefront of all their decision-making.

“We are pleased to have signed this important agreement with the U.S. government to supply the initial 100 million doses upon approval as part of our commitment to address the global health threat. This agreement is one of many steps towards providing global access to a safe and efficacious vaccines for COVID-19. We are also in advanced discussions with multiple other government bodies and we hope to announce additional supply agreements soon. Our goal remains to bring a safe and effective COVID-19 vaccine to many people around the world, as quickly as we can,” said Ugur Sahin, M.D., CEO and Co-founder of BioNTech.

The Pfizer/BioNTech vaccine development program is evaluating at least four experimental vaccines, each of which represents a unique combination of messenger RNA (mRNA) format and target antigen. On July 1st, Pfizer and BioNTech announced preliminary data from BNT162b1, the most advanced of the four mRNA formulations. The early data demonstrates that BNT162b1 is able to produce neutralizing antibodies in humans at or above the levels observed in the plasma from patients who have recovered from COVID-19, and this was shown at relatively low dose levels. Local reactions and systemic events were dose-dependent, generally mild to moderate, and transient. No serious adverse events were reported. On July 20th, the companies announced early positive update from German Phase 1/2 COVID-19 vaccine study, including first T Cell response data.

Recently, two of the companies’ four investigational vaccine candidates (BNT162b1 and BNT162b2) received Fast Track designation from the U.S. Food and Drug Administration (FDA). This designation was granted based on preliminary data from Phase 1/2 studies that are currently ongoing in the United States and Germany as well as animal immunogenicity studies. Further data from the ongoing Phase 1/2 clinical trials of the four vaccine candidates will enable the selection of a lead candidate and dose level for an anticipated large, global Phase 2b/3 safety and efficacy study that may begin as early as later this month, pending regulatory approval.

If the ongoing studies are successful, Pfizer and BioNTech expect to be ready to seek Emergency Use Authorization or some form of regulatory approval as early as October 2020. The companies currently expect to manufacture globally up to 100 million doses by the end of 2020 and potentially more than 1.3 billion doses by the end of 2021, subject to final dose selection from their clinical trial.

In addition to engagements with governments, Pfizer and BioNTech have provided an expression of interest for possible supply to the COVAX Facility, a mechanism established by Gavi, the Vaccine Alliance, the Coalition for Epidemic Preparedness Innovations (CEPI) and World Health Organization (WHO) that aims to provide governments with early access to a large portfolio of COVID-19 candidate vaccines using a range of technology platforms, produced by multiple manufacturers across the world.





Name:   GoneFishin - Email Member
Subject:   Speaking of stupidity
Date:   8/18/2020 4:01:38 PM

You posted what I stated......testing on humans. They are testing it at Yale.

"Pfizer and BioNTech remain on track to begin an anticipated Phase 2b/3 safety and efficacy trial later this month, seek regulatory review as early as October 2020, and manufacture globally up to 100 million doses by the end of 2020 and potentially more than 1.3 billion doses by the end of 2021"

Phase 2b/3 safety and efficacy trial later this month is the trial on humans which I posted. There are probably other tests going on. Even Trump,as idiotic, as his ideas are, can't order untested vacinne be made available to the public. A non issue.





Name:   MartiniMan - Email Member
Subject:   What is your point?
Date:   8/18/2020 4:22:39 PM

They do a certain amount of human trials but at the end of the day you won't really know until the vaccine is used widely.  How many times in the past have approved pharamacuticals been recalled after its been approved by the FDA or ultimately determined not to be effective or whatever? 

Quit picking nits and either answer the question or go away.  I am seriously interested in how many people are going to line up for the first vaccine that is approved for widespread use.  If you don't want to answer that's fine.  But quit wasting our time with your stupid, nitpicky posts.





Name:   architect - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/18/2020 9:01:44 PM

I will take it as soon as it is available.  I won't be first but I am willing to be the 30,001st.  Eventually it will dawn on the usual suspects on this forum that as long as a very large percentage of our population is still uncertain about their safety and insisting on erring on the side of caution, we are not going to have all aspects of our economy fully recover.  It takes the entire country, not just the Trump supporters, feeling safe for the entire country to prosper.





Name:   GoneFishin - Email Member
Subject:   THIS IS MY POINT...............
Date:   8/18/2020 10:41:20 PM

THIS IS MY POINT..."According to research this vaccine approach has never been used in humans  NOW, THAT IS NOT TRUE. I can't imagine anyone would answer your question...Yes, I want to take an untested vaccine. Rather, ask the question..."After testing the vaccine on 30,000 people at Yale Medical, will you get the vaccine if passes the test and become available?" To that I answer YES. To your question, I answer NO.

As to where I should go away to..... we are in the middle of a pandemic and you expect me to just go away....I am safe and sound where I am....not going anywhere dude.





Name:   MartiniMan - Email Member
Subject:   Oh......so you are still wrong
Date:   8/19/2020 7:59:11 AM

Do some research before you go off on me.  As I stated, and it is unequivocally true, this vaccine approach (emphasis added) has never been used on humans.  See below for an explanation and learn to read simple English instead of jumping to stupid conclusions.

The theory behind mRNA vaccines is that when you inject the mRNA (encapsulated within lipid nanoparticles), the mRNA will stimulate your cells to manufacture their own viral proteins.  In this case, those proteins would mimic the proteins found in SARS-CoV-2.

Conventional vaccines train your body to recognize and respond to the proteins of a particular virus by injecting a small amount of the actual viral protein into your body, thereby triggering an immune response and the development of antibodies.

No previous vaccines have had your own cells produce the viral proteins responsible for producing immunity. mRNA vaccines are designed to make your body produce its own viral protein, which your immune system would then mount a response to.

That was exactly what I meant when I said this approach has never been used on humans.  So next time instead of jumping in with some ignorant post how about giving me the benefit of the doubt and asking me what I mean.  And don't tell me that human trials means it has been used on humans because you know exactly what I mean with widespread use of a vaccine.  Lots of things have been tested and tried that have never been approved for use on humans.  At this point I don't even want you to answer the question.  Just go away and find some other thread to hijack with your ignorance.





Name:   MartiniMan - Email Member
Subject:   Now that I'm done schooling Goofy
Date:   8/19/2020 8:02:59 AM

I'll answer my own question.  I am generally not opposed to vaccines and regularly get the flu shot and have all my other vaccinations up to date.  My angst with this particular vaccine is the political and economic pressure to get a vaccine approved.  Were I older or had co-morbidities that make me vulnerable to the virus I would probably take a chance and get it.  But I am only 60, am in good health and dliligently follow all the sensible guidelines so I think I will wait a few months.  Assuming it is not a disaster I will get it.





Name:   Rich - Email Member
Subject:   Poll question - No!
Date:   8/19/2020 10:14:57 AM





Name:   MartiniMan - Email Member
Subject:   Brevity is the soul of wit
Date:   8/19/2020 10:54:04 AM

Short and to the point.....unlike Goofy.





Name:   MAJ USA RET - Email Member
Subject:   Poll question - will you take the vaccine?
Date:   8/20/2020 10:45:00 AM

I am fairly certain that the vaccine will be moot by the time it arrives. Because:

1 - the WuHan will have petered out by the time a vaccine is available -and/or -

2- the virus will have mutated in the normal behavior of viruses - and/or -

3 - herd immunity will be attained (Swedish experience)

 

It is possible that... early in the pandemic... I had the virus (right timing - right symptoms - righ duration).

 

Not especially interested in taking the vaccine.  But, if my pharmacist offers it with next year's flu shot... why not.









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