Name:   MartiniMan - Subject:   Read this RHH....and weep...... Date:   8/26/2020 11:50:11 AM

From a Mayo Clinic study of over 35,000 patients....ya see, this is how you engage in debate and discussion, with facts, logic and reason.  I'll make sure to inform all these "quacks" at lousy places like the Mayo Clinic, Johns Hopkins, etc. that some anonymous dude on the Forum called RHH knows better than them....because according to RHH, "Orange Man Bad" so they must be wrong!!  I am sure they will immediately hand in their M.D. and slink away in shame. /sarc  You are of course free to peer review the paper and let us know all that is wrong with it.  It will be a first if you actually provide something of substance to any conversation here.

Effect of Convalescent Plasma on Mortality Among Hospitalized Patients with COVID-19: Initial Three Month Experience

Michael J. Joyner1 *, M.D., Jonathon W. Senefeld1 , Ph.D., Stephen A. Klassen1 4 , Ph.D., John R. Mills2 , Ph.D., Patrick W. Johnson3 , Elitza S. Theel2 , Ph.D., Chad C. Wiggins1 5 , Ph.D., Katelyn A. Bruno4 , Ph.D., Allan M. Klompas1 6 , M.B., B.Ch., B.A.O., Elizabeth R. Lesser3 , Katie L. Kunze5 , Ph.D., Matthew A. Sexton1 , M.D., Juan C. Diaz Soto1 7 , M.D., Sarah E. Baker1 , Ph.D., John R.A. Shepherd1 , M.D., Noud van Helmond6 8 , M.D., Nigel S. Paneth7,8#, M.D., M.P.H., Ph.D., DeLisa Fairweather4#, Ph.D., R. Scott Wright9,10# 9 , M.D., Rickey E. Carter3#, Ph.D., Arturo Casadevall11# 10 , M.D., Ph.D., the US EAP COVID11 19 Plasma Consortium, US EAP COVID-19 Plasma Consortium: Camille M. van Buskirk2 12 , M.D., Jeffrey L. Winters2 , M.D., James R. Stubbs2 , M.D., Robert F. Rea9 , M.D, David O. Hodge3 13 , Vitaly Herasevich1 , M.D., Ph.D., Emily R. Whelan4 , Andrew J. Clayburn1 , Kathryn F. Larson9 14 , M.D., Juan G. Ripoll1 , M.D., Kylie J. Andersen1 , Matthew R. Buras5 15 , Matthew N.P. Vogt1 , M.D., Joshua J. Dennis1 , Riley J. Regimbal1 , Philippe R. Bauer12 16 , M.D., Ph.D., and Janis E. Blair13 17 , M.D. 18

Affiliations: 1 Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota 2  Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 3  Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida 4  Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida 5  Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona 6  Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University  Health Care, Camden, New Jersey 7  Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State  University, East Lansing, Michigan 8  Department of Pediatrics and Human Development, College of Human Medicine, Michigan  State University, East Lansing, Michigan 9  Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota 10  Human Research Protection Program, Mayo Clinic, Rochester, Minnesota 11  Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of  Public Health, Baltimore, Maryland 12  Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo  Clinic, Rochester, Minnesota 13  Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Phoenix,  Arizona  *Correspondence:  Michael J. Joyner, M.D., Department of Anesthesiology and Perioperative Medicine  Mayo Clinic | 200 First Street SW | Rochester, MN 55905  Drs. Paneth, Fairweather, Wright, Carter and Casadevall contributed equally as senior authors to the work of the study and manuscript.

This version posted August 12, 2020. 

Key Points:

Question. Does transfusion of human convalescent plasma reduce mortality among hospitalized COVID-19 patients? 

Findings. Transfusion of convalescent plasma with higher antibody levels to hospitalized COVID-19 patients significantly reduced mortality compared to transfusions with low antibody levels. Transfusions within three days of COVID-19 diagnosis yielded  greater reductions in mortality.